Melanotan II

Category: peptide

Aliases: MT-II

Pharmacological Mechanism

Non-selective MCR agonist: activates MC1R (melanocortin-1, melanogenesis → tanning), MC3R + MC4R (satiety, energy expenditure), and MC5R (sebum / immune). The MC4R-mediated effects drive appetite suppression and the sexual-response effects that led to the related PT-141 (bremelanotide) development. Unregulated product contamination is common; associated with spontaneous-priapism case reports.

Dosing Guidelines

• SC: Typical 0.5 mg (Range: 0.25–1 mg)

Target Organ Systems

• endocrine
• digestive
• integumentary
• immune-hematologic

Interactions

• PT-141 (synergistic): Bremelanotide is the MC4R-preferring metabolite of MT-II. Do not stack.

Pathways It Modulates

• Melanocortin receptor axis (activator) — MC1R + MC3R + MC4R (nonselective)

Chemical Identifiers

• PubChem CID: 92432
• Formula: C50H69N15O9
• Molecular weight: 1024.2 g/mol
• InChIKey: JDKLPDJLXHXHNV-MFVUMRCOSA-N
• SMILES: CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C