Adenosine

Category: nucleoside

Aliases: Adenine riboside

Pharmacological Mechanism

Endogenous signalling nucleoside acting at four GPCR subtypes: A1 (cardiac slowing, inhibition of NE release), A2A (vasodilation, wakefulness suppression — caffeine's principal target), A2B, A3. Accumulates with neural activity and is the presumed somnogen driving sleep pressure. Extremely short plasma t½ (seconds) — deaminated to inosine by adenosine deaminase.

Half-Life (t½)

IV: 0.0028h

Dosing Guidelines

Target Organ Systems

Interactions