Polyene Antibiotics

Comprises a class of antifungal drugs characterized by a large macrolide ring with multiple conjugated double bonds, interacting with fungal membrane sterols.

Key Functions:

• Bind to ergosterol in fungal cell membranes, forming pores.
• Disrupt membrane integrity, leading to leakage of cellular contents.
• Used to treat systemic fungal infections.

Interacting Systems & Components:

• Fungi (target of action)
• Ergosterol (fungal membrane sterol, target)
• Cell Membrane (disrupts fungal membrane)