Pravastatin

Category: pharmacological

Aliases: Pravachol

Pharmacological Mechanism

Hydrophilic — low hepatocellular + CNS penetration → fewer interactions + fewer CNS side effects. Minimal CYP metabolism (sulfation pathway). Good choice for patients on complex interaction profiles.

Half-Life (t½)

PO: 1.8h

Dosing Guidelines

• PO: Typical 33.3 mg (Range: 10–80 mg)

Target Organ Systems

• digestive

Pathways It Modulates

• Atherosclerosis plaque pathology (inhibitor) — HMG-CoA reductase (hydrophilic — fewer DDIs)
• Cholesterol synthesis (inhibitor) — HMG-CoA reductase

Chemical Identifiers

• PubChem CID: 54687
• Formula: C23H36O7
• Molecular weight: 424.53 g/mol
• InChIKey: TUZYXOIXSAXUGO-PZAWKZKUSA-N
• SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@H](C[C@H](CC(=O)O)O)O)O

References

• PMID 11192473