Pramipexole

Category: pharmacological

Aliases: Mirapex

Pharmacological Mechanism

Non-ergot dopamine agonist with preferential affinity for the D3 receptor (within the D2 receptor family); first-line for Parkinson's disease and restless legs syndrome.

Half-Life (t½)

PO: 8h

Dosing Guidelines

• PO: Typical 0.5 mg (Range: 0.125–1.5 mg)

Target Organ Systems

• nervous

Notes

PK from FDA prescribing information (DailyMed setid 46f88017-7b0e-437e-90b1-37bdf9013e72): absolute bioavailability >90% (F 0.9), apparent Vd ~500 L, terminal t½ ~8 h (young)/~12 h (elderly), Tmax ~2 h, ~90% excreted unchanged in urine. ka_hr 1.5 derived from Tmax 2 h (ke from t½ 8 h). Human D2 affinity not authored — GtoPdb's curated human range (pKi 5.1–7.4) is too wide to pin a value.

Chemical Identifiers

• PubChem CID: 119570
• Formula: C10H17N3S
• Molecular weight: 211.33 g/mol
• InChIKey: FASDKYOPVNHBLU-ZETCQYMHSA-N
• SMILES: CCCN[C@H]1CCC2=C(C1)SC(=N2)N

References

• PMID 7756621
• PMID 37600497