Ibogaine

Category: alkaloid

Aliases: iboga, 12-methoxyibogamine

Pharmacological Mechanism

Iboga alkaloid with anti-addiction interest (suppresses opioid withdrawal and craving). Polypharmacology — NMDA-receptor antagonist, sigma-1/2, kappa- and mu-opioid, SERT, nicotinic — NOT primarily a 5-HT2A drug. CYP2D6 converts it to the long-lived active metabolite noribogaine. Major risk: QT prolongation → torsades / cardiac arrest.

Half-Life (t½)

PO: 10.2h

Dosing Guidelines

• PO: Typical 1000mg (Range: 200 - 1200 )

Target Organ Systems

• nervous
• cardiovascular