Category: pharmacological
Aliases: Androxal, enclomifene, (E)-clomiphene, trans-clomiphene
The trans-(E)-isomer of clomiphene, a selective estrogen receptor modulator (SERM). It antagonizes estrogen receptors at the hypothalamus, blocking estradiol negative feedback so GnRH pulse frequency rises, driving pituitary LH/FSH and consequently endogenous testicular testosterone. Unlike exogenous testosterone it preserves spermatogenesis, making it attractive for secondary hypogonadism and post-cycle therapy.
PubChem CID 1548953 (free base, E-isomer). No abstract names an enclomiphene half-life (Ghobadi 2009 PMID:19033451 states it "could not be determined due to a very flat terminal half-life"). Occupancy SKIP — only verbatim value is an antagonist IC50 (77 nM, Fitzpatrick 1999 PMID:10465261), incompatible with the agonist model (see AUTHORING_GAPS).