Category: pharmacological
Aliases: Androxal, enclomifene, (E)-clomiphene, trans-clomiphene
The trans-(E)-isomer of clomiphene, a selective estrogen receptor modulator (SERM). It antagonizes estrogen receptors at the hypothalamus, blocking estradiol negative feedback so GnRH pulse frequency rises, driving pituitary LH/FSH and consequently endogenous testicular testosterone. Unlike exogenous testosterone it preserves spermatogenesis, making it attractive for secondary hypogonadism and post-cycle therapy.