Dutasteride

Category: hormone

Aliases: Avodart

Pharmacological Mechanism

Inhibits both type I and type II isoforms of 5α-reductase, preventing conversion of testosterone to dihydrotestosterone (DHT). Reduces serum DHT by >90% (vs ~70% for finasteride which only blocks type II). Used for benign prostatic hyperplasia and androgenic alopecia.

Half-Life (t½)

PO: 840h

Dosing Guidelines

• PO: Typical 0.5mg (Range: 0.5 - 0.5 mg)

Target Organ Systems

• endocrine
• reproductive
• integumentary

Interactions

• Finasteride